In the MCU, the Sanctum Sanctorum helps create a protective mystic barrier around the Earth, but in the comics, it has a more colorful history!
Doctor Strange has one of the weirdest houses in the entire Marvel Universe. Called the Sanctum Sanctorum, this three-story townhouse located at 177A Bleecker Street in New York’s Greenwich Village stores many of Strange’s mystical artifacts and is a labyrinth of rooms – some of which exist in different dimensions. In the MCU, the New York Sanctum is said to be one of three such buildings (with the others being in Hong Kong and London) that form a protective barrier around the world, shielding it from other-dimensional threats.
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